SCHEMBL19976926

SCHEMBL19976926

CC(C)CN/C(=N/C(=O)c1ccc(F)c(F)c1)Nc1n[nH]c2cccnc12

nearest known ligand 0.48

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
GRM4 Q14833 19/20 0.48
DYRK1A Q13627 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19976846 0.86 KDM4E (0.42) DYRK1A
SCHEMBL19976766 0.85 ABL1 (0.43) DYRK1A
SCHEMBL19976866 0.84 DYRK1A (0.42) DYRK1A
SCHEMBL19976776 0.81 GSK3B (0.48) DYRK1A
SCHEMBL19976854 0.81 GSK3B (0.42) DYRK1A
SCHEMBL19976789 0.80 GSK3B (0.42) DYRK1A
SCHEMBL19976857 0.80 MAPK1 (0.35) DYRK1A
SCHEMBL19976758 0.79 DYRK1A (0.40) DYRK1A
SCHEMBL19976767 0.79 GSK3B (0.51)
SCHEMBL19976780 0.78 LMNA (0.33) DYRK1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9920012-B2 Indazole guanidine F1F0-ATPase inhibitors and therapeutic uses thereof LYCERA CORPORATION (US) 2018-03-20 US disclosed