Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.32 |
| ▸ | TDO2 | P48775 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.31 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.31 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18556892 | 0.81 | PKM (0.33) | PKMMAPTSMN1; SMN2POLBHDAC3 | |
| SCHEMBL24656034 | 0.80 | PKM (0.33) | PKMMAPTHTR2ASMN1; SMN2 | |
| SCHEMBL19976890 | 0.79 | LMNA (0.39) | MAPTSMN1; SMN2KCNH2ALDH1A1GAA | |
| SCHEMBL27668309 | 0.76 | ALDH1A1 (0.40) | HTR2AKCNH2ALDH1A1GAACRHR1 | |
| SCHEMBL23588362 | 0.75 | PKM (0.39) | PKMMAPTHTR2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL19697077 | 0.75 | MC4R (0.42) | PKMKCNH2ALDH1A1CRHR1IDO1 | |
| SCHEMBL2632720 | 0.71 | KCNH2 (0.42) | PKMHTR2AKCNH2ALDH1A1CRHR1 | |
| SCHEMBL24656100 | 0.70 | PKM (0.35) | PKMHTR2A | |
| SCHEMBL13637255 | 0.69 | KCNH2 (0.38) | PKMHTR2AKCNH2CRHR1POLB | |
| SCHEMBL18713690 | 0.69 | KDM4E (0.44) | SMN1; SMN2KCNH2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9920012-B2 | Indazole guanidine F1F0-ATPase inhibitors and therapeutic uses thereof | LYCERA CORPORATION (US) | 2018-03-20 | — | — | US | disclosed |