Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.34 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26665293 | 0.79 | HTT (0.47) | LMNAHTTTP53ALDH1A1RAB9A | |
| SCHEMBL19976867 | 0.79 | PKM (0.36) | KCNH2ALDH1A1MAPTGAAIDO1 | |
| SCHEMBL19068767 | 0.76 | HTT (0.34) | LMNAHTTTP53KCNH2ALDH1A1 | |
| SCHEMBL20856563 | 0.76 | LMNA (0.38) | LMNAHTTTP53ALDH1A1KDM4E | |
| SCHEMBL18593511 | 0.73 | KCNH2 (0.41) | LMNAHTTTP53KCNH2ALDH1A1 | |
| SCHEMBL17247748 | 0.72 | TP53 (0.44) | LMNAHTTTP53KCNH2ALDH1A1 | |
| SCHEMBL19987482 | 0.72 | KCNH2 (0.47) | LMNAHTTTP53KCNH2 | |
| SCHEMBL16676250 | 0.69 | DDR1 (0.39) | LMNAHTTKCNH2ALDH1A1KDM4E | |
| SCHEMBL20032503 | 0.69 | GCG (0.39) | LMNAHTTTP53KCNH2MAPT | |
| SCHEMBL16529426 | 0.69 | CCR2 (0.46) | ALDH1A1KDM4ERAB9AMAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9920012-B2 | Indazole guanidine F1F0-ATPase inhibitors and therapeutic uses thereof | LYCERA CORPORATION (US) | 2018-03-20 | — | — | US | disclosed |