Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 2/20 | 0.48 |
| ▸ | BCHE | P06276 | 1/20 | 0.48 |
| ▸ | S1PR1 | P21453 | 10/20 | 0.37 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.37 |
| ▸ | S1PR3 | Q99500 | 5/20 | 0.37 |
| ▸ | TP53 | P04637 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19980507 | 0.81 | ACHE (0.53) | ACHEBCHES1PR1AOC3S1PR3 | |
| SCHEMBL22710136 | 0.75 | AAK1 (0.37) | ACHEBCHEAOC3 | |
| SCHEMBL22048696 | 0.75 | AAK1 (0.37) | ACHEBCHEAOC3 | |
| SCHEMBL23085605 | 0.73 | CCR5 (0.52) | POLBLMNAKDM4E | |
| SCHEMBL10171195 | 0.68 | S1PR1 (0.69) | S1PR1S1PR3MAPTSMN1; SMN2LMNA | |
| SCHEMBL25077636 | 0.68 | MEN1 (0.36) | MAPT | |
| SCHEMBL23085712 | 0.68 | CCR5 (0.35) | AOC3SMN1; SMN2KDM4E | |
| SCHEMBL19980174 | 0.67 | AOC3 (0.41) | S1PR1AOC3S1PR3TP53MAPT | |
| SCHEMBL14320203 | 0.67 | ALDH1A1 (0.43) | TP53MAPTSMN1; SMN2KDM4E | |
| SCHEMBL19980293 | 0.67 | ACHE (0.58) | ACHEBCHES1PR1AOC3S1PR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2956452-B1 | HETEROCYCLIC AMIDES AS KINASE INHIBITORS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2018-03-21 | — | — | EP | disclosed |