Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 3/20 | 0.53 |
| ▸ | BCHE | P06276 | 2/20 | 0.53 |
| ▸ | S1PR1 | P21453 | 13/20 | 0.39 |
| ▸ | S1PR3 | Q99500 | 6/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19980257 | 0.82 | HTR1D (0.41) | S1PR1S1PR3SMN1; SMN2KDM4EHSD17B10 | |
| SCHEMBL23189282 | 0.81 | HPGD (0.38) | S1PR1SMN1; SMN2KDM4ENPC1RAB9A | |
| SCHEMBL19980133 | 0.81 | ACHE (0.48) | ACHEBCHES1PR1S1PR3SMN1; SMN2 | |
| SCHEMBL21155980 | 0.77 | NOTUM (0.45) | KDM4EHSD17B10 | |
| SCHEMBL20344681 | 0.74 | CYP1A2 (0.45) | S1PR1SMN1; SMN2KDM4ENPC1RAB9A | |
| SCHEMBL22710190 | 0.74 | ROCK2 (0.48) | — | |
| SCHEMBL20344598 | 0.72 | HPGD (0.38) | S1PR1SMN1; SMN2KDM4ENPC1RAB9A | |
| SCHEMBL22048701 | 0.72 | KMT2A (0.47) | SMN1; SMN2KDM4ENPC1RAB9AHSD17B10 | |
| SCHEMBL19980139 | 0.72 | CSNK2A1 (0.40) | SMN1; SMN2KDM4EHSD17B10MAPT | |
| SCHEMBL19980436 | 0.72 | HTR2C (0.41) | KDM4EHSD17B10MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2956452-B1 | HETEROCYCLIC AMIDES AS KINASE INHIBITORS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2018-03-21 | — | — | EP | disclosed |