Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 10/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22048691 | 0.89 | ACACB (0.42) | RIPK1IDO1EPHX2GAAMAPK10 | |
| SCHEMBL21156303 | 0.82 | GAA (0.35) | IDO1KDM4EALDH1A1HPGDEPHX2 | |
| SCHEMBL3485743 | 0.81 | GAA (0.57) | RIPK1IDO1EPHX2GAAMAPK10 | |
| SCHEMBL1561667 | 0.81 | GAA (0.57) | RIPK1IDO1EPHX2GAAMAPK10 | |
| SCHEMBL1561665 | 0.81 | GAA (0.57) | RIPK1IDO1EPHX2GAAMAPK10 | |
| SCHEMBL31213772 | 0.75 | DRD2 (0.41) | IDO1KDM4EALDH1A1HPGDEPHX2 | |
| SCHEMBL29960414 | 0.74 | IDO1 (0.48) | IDO1ALDH1A1EPHX2MAPK10PARP1 | |
| SCHEMBL18368150 | 0.74 | RIPK1 (0.52) | RIPK1IDO1EPHX2GAAMAPK10 | |
| SCHEMBL21156863 | 0.74 | RIPK1 (0.52) | RIPK1IDO1EPHX2GAAMAPK10 | |
| SCHEMBL31544619 | 0.74 | MTNR1A (0.67) | ALDH1A1HPGDTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2956452-B1 | HETEROCYCLIC AMIDES AS KINASE INHIBITORS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2018-03-21 | — | — | EP | disclosed |