Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.31 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.30 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20344607 | 0.69 | ALDH1A1 (0.37) | ALDH1A1SMN1; SMN2MEN1KMT2AHPGD | |
| SCHEMBL20344640 | 0.63 | ALOX15 (0.42) | SMN1; SMN2TSHRMEN1KMT2AHTT | |
| SCHEMBL22048476 | 0.63 | MEN1 (0.40) | ALDH1A1SMN1; SMN2ATMMAPK1MEN1 | |
| SCHEMBL5323948 | 0.62 | ALDH1A1 (0.63) | ALDH1A1SMN1; SMN2MEN1KMT2AHPGD | |
| SCHEMBL19979980 | 0.62 | KDM4E (0.46) | ALDH1A1SMN1; SMN2MEN1KMT2ACYP2C19 | |
| SCHEMBL23188943 | 0.61 | CNR2 (0.38) | TSHRMEN1KMT2ACYP2C9CYP2C19 | |
| SCHEMBL22048475 | 0.61 | SMN1; SMN2 (0.45) | ALDH1A1SMN1; SMN2MAPK1MEN1KMT2A | |
| SCHEMBL11080103 | 0.59 | VNN1 (0.52) | — | |
| SCHEMBL23188871 | 0.59 | SMN1; SMN2 (0.41) | ALDH1A1SMN1; SMN2MAPK1MEN1KMT2A | |
| SCHEMBL10137784 | 0.58 | SLC1A1 (0.46) | TSHRMEN1KMT2ACYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2956452-B1 | HETEROCYCLIC AMIDES AS KINASE INHIBITORS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2018-03-21 | — | — | EP | disclosed |