Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.34 |
| ▸ | KDM4C | Q9H3R0 | 3/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 4/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 4/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | HRH2 | P25021 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19980650 | 0.91 | DRD2 (0.34) | PTGDR2KDM4CHCRTR1HCRTR2MEN1 | |
| SCHEMBL19980685 | 0.88 | KDM4C (0.36) | PTGDR2KDM4CMEN1KMT2A | |
| SCHEMBL26036581 | 0.88 | RORC (0.34) | PTGDR2KDM4CHCRTR1HCRTR2DRD2 | |
| SCHEMBL19972527 | 0.88 | MEN1 (0.32) | PTGDR2KDM4CHCRTR1HCRTR2MEN1 | |
| SCHEMBL23515871 | 0.86 | KDM4C (0.36) | PTGDR2KDM4CMEN1KMT2APIM2 | |
| SCHEMBL19972686 | 0.86 | KDM4C (0.36) | PTGDR2KDM4CMEN1KMT2APIM2 | |
| SCHEMBL19972688 | 0.86 | KDM4C (0.36) | PTGDR2KDM4CMEN1KMT2APIM2 | |
| SCHEMBL25135370 | 0.86 | HTR6 (0.41) | DRD2SLC6A4HRH2 | |
| SCHEMBL29985977 | 0.86 | HTR6 (0.38) | MEN1KMT2ADRD2SLC6A4 | |
| SCHEMBL19972555 | 0.86 | HTR6 (0.38) | MEN1KMT2ADRD2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4230627-A2 | INHIBITORS OF THE MENIN-MLL INTERACTION | Vitae Pharmaceuticals, LLC (US) | 2023-08-23 | — | — | EP | disclosed |
| EP-3512850-B1 | INHIBITORS OF THE MENIN-MLL INTERACTION | VITAE PHARMACEUTICALS LLC (US) | 2023-04-12 | — | — | EP | disclosed |
| WO-2018053267-A1 | INHIBITORS OF THE MENIN-MLL INTERACTION | VITAE PHARMACEUTICALS, INC. (US) | 2018-03-22 | — | — | WO | disclosed |