Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 7/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 7/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 7/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10512635 | 0.98 | NPC1 (0.35) | NPC1RAB9ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL2836592 | 0.83 | GAA (0.32) | NPC1RAB9A | |
| SCHEMBL2838035 | 0.83 | NPC1 (0.36) | NPC1RAB9ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL2840194 | 0.81 | NPC1 (0.35) | NPC1RAB9ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL2835826 | 0.79 | RAD52 (0.32) | — | |
| SCHEMBL2836955 | 0.72 | SLC6A2 (0.38) | SLC6A2SLC6A4SLC6A3CYP2D6 | |
| SCHEMBL10513171 | 0.71 | PNMT (0.31) | — | |
| SCHEMBL11000109 | 0.71 | SLC6A2 (0.46) | NPC1RAB9ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL11005061 | 0.71 | SLC6A4 (0.58) | NPC1RAB9ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL19981716 | 0.71 | UGT2B17 (0.38) | RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8217031-B2 | Heteroaryl derivatives | NIPPON SHINYAKU CO., LTD. (JP) | 2012-07-10 | — | — | US | disclosed |
| US-20100048537-A1 | HETEROARYL DERIVATIVES | NIPPON SHINYAKU CO., LTD. (JP) | 2010-02-25 | — | — | US | disclosed |
| EP-2141168-A1 | HETEROARYL DERIVATIVES | Nippon Shinyaku Co., Ltd. (JP) | 2010-01-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100048537-A1 | HETEROARYL DERIVATIVES | OPRD1, OPRM1, OPRK1 | NPC1 1665/4885RAB9A 1933/4885SLC6A2 196/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.