Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
| ▸ | NR1D1 | P20393 | 1/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 5/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 5/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.31 |
| ▸ | RORC | P51449 | 1/20 | 0.30 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.30 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.30 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.30 |
| ▸ | CFD | P00746 | 1/20 | 0.30 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.30 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.30 |
| ▸ | RXRA | P19793 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16626643 | 0.90 | BACE1 (0.35) | BACE1NR1D1GRIN1GRIN2BPRMT5 | |
| SCHEMBL16626085 | 0.86 | ROCK2 (0.36) | GRIN1GRIN2BKCNH2RORCROCK2 | |
| SCHEMBL16626776 | 0.86 | GRM5 (0.35) | GRIN1GRIN2BKCNH2RORCCFD | |
| SCHEMBL16626586 | 0.82 | EPHX2 (0.38) | NR1D1HDAC8 | |
| SCHEMBL16626779 | 0.78 | RORC (0.50) | BACE1NR1D1GRIN1GRIN2BRORC | |
| Hydrochloric Acid SCHEMBL16618992 | 0.77 | RORC (0.49) | BACE1NR1D1GRIN1GRIN2BRORC | |
| SCHEMBL17971575 | 0.74 | RORC (0.43) | BACE1NR1D1PDE4BRORC | |
| Hydrochloric Acid SCHEMBL16619474 | 0.74 | RORC (0.42) | BACE1NR1D1PDE4BRORC | |
| SCHEMBL16626590 | 0.73 | L3MBTL1 (0.33) | NR1D1 | |
| SCHEMBL16626086 | 0.70 | GRIN2B (0.38) | GRIN1GRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3052484-B1 | SULFONYLINDOLE DERIVATIVES AND METHOD FOR PREPARING THE SAME | DAE WOONG PHARMA (KR) | 2018-03-21 | — | — | EP | disclosed |