Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AHR | P35869 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.43 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.40 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2004951 | 0.90 | AHR (0.54) | AHRLMNAALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL2003582 | 0.88 | LMNA (0.46) | AHRLMNAALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL2012463 | 0.87 | LMNA (0.56) | AHRLMNAALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL2002249 | 0.87 | LMNA (0.47) | AHRLMNAALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL2004829 | 0.86 | AHR (0.50) | AHRLMNAALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL2002890 | 0.86 | AHR (0.49) | AHRLMNAALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL2003656 | 0.86 | AHR (0.49) | AHRLMNAALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL2004404 | 0.86 | AHR (0.49) | AHRLMNAALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL2005673 | 0.85 | LMNA (0.49) | AHRLMNAALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL2006378 | 0.84 | LMNA (0.47) | AHRLMNAALDH1A1SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960544-B2 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |