Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | AHR | P35869 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.48 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.46 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | RGS12 | O14924 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2004829 | 0.92 | AHR (0.50) | LMNAALDH1A1AHRMAPTPLA2G2A | |
| SCHEMBL2002890 | 0.92 | AHR (0.49) | LMNAALDH1A1AHRMAPTPLA2G2A | |
| SCHEMBL2004951 | 0.89 | AHR (0.54) | LMNAALDH1A1AHRMAPTPLA2G2A | |
| SCHEMBL1998380 | 0.87 | AHR (0.49) | LMNAALDH1A1AHRMAPTPLA2G2A | |
| SCHEMBL2007187 | 0.86 | LMNA (0.55) | LMNAALDH1A1AHRMAPTPLA2G2A | |
| SCHEMBL2003062 | 0.85 | LMNA (0.55) | LMNAALDH1A1AHRMAPTPLA2G2A | |
| SCHEMBL2004404 | 0.85 | AHR (0.49) | LMNAALDH1A1AHRMAPTPLA2G2A | |
| SCHEMBL2003656 | 0.85 | AHR (0.49) | LMNAALDH1A1AHRMAPTPLA2G2A | |
| SCHEMBL2012914 | 0.84 | LMNA (0.56) | LMNAALDH1A1AHRMAPTPLA2G2A | |
| SCHEMBL2003979 | 0.82 | AHR (0.53) | LMNAALDH1A1AHRMAPTPLA2G2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960544-B2 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |