Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AHR | P35869 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.45 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.42 |
| ▸ | APOBEC3B | Q9UH17 | 1/20 | 0.42 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.42 |
| ▸ | TUBB | P07437 | 1/20 | 0.42 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.42 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.42 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.42 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.42 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.42 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.42 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.42 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2012463 | 0.92 | LMNA (0.56) | AHRLMNAALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL2002890 | 0.91 | AHR (0.49) | AHRLMNAALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL2003656 | 0.89 | AHR (0.49) | AHRLMNAALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL2004404 | 0.87 | AHR (0.49) | AHRLMNAALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL2004951 | 0.86 | AHR (0.54) | AHRLMNAALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL1998380 | 0.86 | AHR (0.49) | AHRLMNAALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL2004801 | 0.86 | LMNA (0.47) | AHRLMNAALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL2008365 | 0.86 | AHR (0.51) | AHRLMNAALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL2003635 | 0.86 | LMNA (0.48) | AHRLMNAALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL2005436 | 0.85 | LMNA (0.48) | AHRLMNAALDH1A1SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960544-B2 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |