SCHEMBL19983916

SCHEMBL19983916

CNCc1cn(Sc2cncc(F)c2)c2cc(Nc3ccc(C)cc3F)ccc12

nearest known ligand 0.30

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19983933 0.85 KDM4E (0.32) KDM4E
SCHEMBL19983954 0.83 HTR2A (0.32) KDM4E
SCHEMBL19983888 0.82 P2RX7 (0.31) KDM4E
SCHEMBL19984181 0.81 TRPV1 (0.30)
SCHEMBL19983915 0.80 MKNK2 (0.35)
SCHEMBL16626727 0.79 PDE4A (0.38)
SCHEMBL19984127 0.79 NUDT1 (0.36)
Hydrochloric Acid SCHEMBL16618725 0.78 PDE4A (0.38)
SCHEMBL19983721 0.78 HTR2C (0.32)
SCHEMBL19983844 0.78 ALDH1A1 (0.35) KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3052484-B1 SULFONYLINDOLE DERIVATIVES AND METHOD FOR PREPARING THE SAME DAE WOONG PHARMA (KR) 2018-03-21 EP disclosed