SCHEMBL19983943

SCHEMBL19983943

CNCc1c[nH]c2cc(Nc3ccc(Cl)nc3Cl)ncc12

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 4/20 0.36
CYP2C19 P33261 2/20 0.36
TTK P33981 3/20 0.32
AURKA O14965 2/20 0.32
CCNA2 P20248 2/20 0.32
CDK2 P24941 2/20 0.32
GPR84 Q9NQS5 1/20 0.32
CYP2D6 P10635 1/20 0.31
TDO2 P48775 1/20 0.31
CHRNB2 P17787 1/20 0.30
CHRNA7 P36544 1/20 0.30
CHRNA4 P43681 1/20 0.30
CYP1A2 P05177 1/20 0.30
SYK P43405 1/20 0.30
LCK P06239 1/20 0.30
PGR P06401 1/20 0.30
CSF1R P07333 1/20 0.30
CHRM2 P08172 1/20 0.30
HTR1A P08908 1/20 0.30
ADRA2A P08913 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19983894 0.82 GPR84 (0.39) CYP3A4CYP2C19GPR84CYP2D6CHRNB2
SCHEMBL19984249 0.81 TDO2 (0.41) CYP3A4CYP2C19TTKAURKACCNA2
SCHEMBL19984048 0.78 TDO2 (0.42) GPR84TDO2SLC6A4
SCHEMBL19984194 0.73 GPR84 (0.39) CYP2C19GPR84CYP2D6CHRNB2CHRNA7
SCHEMBL19983972 0.72 GPR84 (0.40) CYP3A4CYP2C19GPR84CYP2D6CHRNB2
SCHEMBL19983800 0.70 GPR84 (0.36) CYP2C19CDK2GPR84CYP2D6CHRNB2
SCHEMBL19983877 0.70 GPR84 (0.36) GPR84CHRNB2CHRNA7CHRNA4
SCHEMBL16626544 0.70 GPR84 (0.36) GPR84CHRNB2CHRNA7CHRNA4
SCHEMBL19984043 0.70
SCHEMBL19983731 0.69 GPR84 (0.37) CYP3A4CYP2C19GPR84CYP2D6TDO2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3052484-B1 SULFONYLINDOLE DERIVATIVES AND METHOD FOR PREPARING THE SAME DAE WOONG PHARMA (KR) 2018-03-21 EP disclosed