Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CES2 | O00748 | 1/20 | 0.39 |
| ▸ | CES1 | P23141 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19984819 | 0.87 | LMNA (0.44) | LMNATSHRKDM4EL3MBTL1ADRA2A | |
| SCHEMBL19984686 | 0.87 | IDO1 (0.47) | LMNAMAPK1TSHRKDM4EL3MBTL1 | |
| SCHEMBL19984817 | 0.82 | ACP3 (0.54) | LMNATSHRL3MBTL1CYP2D6ALDH1A1 | |
| SCHEMBL19984685 | 0.82 | TSHR (0.46) | TSHRCYP2D6 | |
| SCHEMBL26067052 | 0.77 | — | — | |
| SCHEMBL2336389 | 0.77 | — | — | |
| SCHEMBL4348933 | 0.77 | LMNA (0.48) | LMNAMAPK1TSHRKDM4EL3MBTL1 | |
| SCHEMBL448348 | 0.75 | DPP4 (0.53) | LMNAMAPK1TSHRCYP2D6SRC | |
| SCHEMBL26608146 | 0.74 | ADRA2C (0.54) | LMNAMAPK1TSHRKDM4EADRA2A | |
| SCHEMBL19984778 | 0.74 | TSHR (0.54) | LMNAMAPK1TSHRKDM4EL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2306986-B1 | PRODRUGS AND DRUG-MACROMOLECULE CONJUGATES HAVING CONTROLLED DRUG RELEASE RATES | PROLYNX LLC (US) | 2018-03-21 | — | — | EP | disclosed |