Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | CNR1 | P21554 | 2/20 | 0.41 |
| ▸ | CNR2 | P34972 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.41 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | TACR1 | P25103 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.38 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19984820 | 0.87 | LMNA (0.44) | LMNAL3MBTL1TSHRKDM4EADRA2A | |
| SCHEMBL17923689 | 0.82 | LMNA (0.53) | LMNACNR1CNR2TSHRALOX12 | |
| SCHEMBL12199145 | 0.82 | LMNA (0.53) | LMNACNR1CNR2TSHRALOX12 | |
| SCHEMBL15617630 | 0.81 | LMNA (0.46) | LMNACNR1CNR2L3MBTL1KEAP1 | |
| SCHEMBL29001569 | 0.79 | LMNA (0.49) | LMNACNR1CNR2KEAP1NFE2L2 | |
| SCHEMBL19984686 | 0.79 | IDO1 (0.47) | LMNACNR1CNR2L3MBTL1TSHR | |
| SCHEMBL19984817 | 0.79 | ACP3 (0.54) | LMNACNR1CNR2L3MBTL1TSHR | |
| SCHEMBL477385 | 0.78 | LMNA (0.50) | LMNACNR1CNR2L3MBTL1KEAP1 | |
| SCHEMBL477533 | 0.78 | LMNA (0.50) | LMNACNR1CNR2L3MBTL1KEAP1 | |
| SCHEMBL17118213 | 0.78 | LMNA (0.48) | LMNACNR1CNR2TSHRALOX12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2306986-B1 | PRODRUGS AND DRUG-MACROMOLECULE CONJUGATES HAVING CONTROLLED DRUG RELEASE RATES | PROLYNX LLC (US) | 2018-03-21 | — | — | EP | disclosed |