Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | MITF | O75030 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.40 |
| ▸ | RAF1 | P04049 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ATR | Q13535 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | CDK8 | P49336 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19984978 | 0.86 | TSHR (0.39) | ALDH1A1SMN1; SMN2TSHRNPC1RAB9A | |
| SCHEMBL19984843 | 0.78 | NAMPT (0.49) | ALDH1A1SMN1; SMN2TSHRNPC1RAB9A | |
| SCHEMBL19866357 | 0.74 | CD274 (0.52) | MEN1KMT2A | |
| SCHEMBL18078725 | 0.74 | CD274 (0.52) | MEN1KMT2A | |
| SCHEMBL19984831 | 0.70 | LRRK2 (0.35) | ALDH1A1SMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL14517931 | 0.69 | KDM4E (0.74) | ALDH1A1SMN1; SMN2TSHRNPC1RAB9A | |
| SCHEMBL19973940 | 0.67 | MAPK1 (0.33) | MEN1KMT2A | |
| SCHEMBL19984804 | 0.66 | GAA (0.45) | ALDH1A1SMN1; SMN2TSHRNPC1RAB9A | |
| SCHEMBL19984850 | 0.65 | HDAC6 (0.40) | NPC1RAB9AGAAMAPTHTT | |
| SCHEMBL19984811 | 0.65 | KDM4E (0.43) | ALDH1A1SMN1; SMN2NPC1RAB9ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018051255-A1 | CYCLIC SUBSTITUTED-1,3,4-OXADIAZOLE AND THIADIAZOLE COMPOUNDS AS IMMUNOMODULATORS | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2018-03-22 | — | — | WO | disclosed |