Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 4/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | MITF | O75030 | 1/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19984848 | 0.78 | ALDH1A1 (0.43) | SMN1; SMN2ALDH1A1RAB9ATSHRNPC1 | |
| SCHEMBL14517931 | 0.73 | KDM4E (0.74) | SMN1; SMN2ALDH1A1RAB9ATSHRNPC1 | |
| SCHEMBL19984978 | 0.73 | TSHR (0.39) | SMN1; SMN2ALDH1A1RAB9APKMTSHR | |
| SCHEMBL11615122 | 0.73 | NAMPT (0.83) | NAMPTSMN1; SMN2ALDH1A1RAB9ANPC1 | |
| SCHEMBL8176742 | 0.69 | SMN1; SMN2 (0.81) | NAMPTSMN1; SMN2RAB9APKMMAPK1 | |
| SCHEMBL15573138 | 0.68 | RAF1 (0.74) | NAMPTSMN1; SMN2ALDH1A1RAB9ANPC1 | |
| SCHEMBL13480581 | 0.68 | MTNR1B (0.72) | SMN1; SMN2ALDH1A1RAB9APKMMAPK1 | |
| SCHEMBL4893387 | 0.67 | TP53 (0.87) | SMN1; SMN2ALDH1A1RAB9AMAPK1TSHR | |
| SCHEMBL31040569 | 0.67 | TP53 (0.87) | SMN1; SMN2ALDH1A1RAB9AMAPK1TSHR | |
| SCHEMBL5756200 | 0.67 | RAB9A (0.77) | NAMPTSMN1; SMN2ALDH1A1RAB9APKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018051255-A1 | CYCLIC SUBSTITUTED-1,3,4-OXADIAZOLE AND THIADIAZOLE COMPOUNDS AS IMMUNOMODULATORS | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2018-03-22 | — | — | WO | disclosed |