Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 7/20 | 0.35 |
| ▸ | PLK1 | P53350 | 4/20 | 0.35 |
| ▸ | CES2 | O00748 | 3/20 | 0.35 |
| ▸ | GMNN | O75496 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | ESR1 | P03372 | 3/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.33 |
| ▸ | THRA | P10827 | 6/20 | 0.33 |
| ▸ | FAAH | O00519 | 4/20 | 0.33 |
| ▸ | CES1 | P23141 | 4/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | PLA2G6 | O60733 | 1/20 | 0.33 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29191780 | 0.71 | MGLL (0.48) | THRBCES2GMNNTP53POLB | |
| SCHEMBL17424798 | 0.70 | GMNN (0.49) | THRBPLK1CES2GMNNTP53 | |
| SCHEMBL22869142 | 0.69 | THRB (0.44) | THRBPLK1CYP2C9HSD17B10THRA | |
| SCHEMBL29191779 | 0.68 | PLA2G4B (0.41) | THRBCES2GMNNTP53POLB | |
| SCHEMBL22907692 | 0.65 | ESR1 (0.36) | THRBCES2GMNNTP53POLB | |
| SCHEMBL23953303 | 0.65 | CYP1A2 (0.39) | MAPTCYP2C9MEN1KMT2A | |
| SCHEMBL7892788 | 0.63 | PTGS2 (0.41) | THRBCES2GMNNTP53POLB | |
| SCHEMBL14463212 | 0.62 | MAPT (0.40) | THRBCES2GMNNTP53POLB | |
| SCHEMBL17399693 | 0.60 | HSD17B3 (0.63) | THRBCES2GMNNTP53POLB | |
| SCHEMBL23009130 | 0.59 | TYR (0.56) | TP53MAPTCYP2C9HSD17B10ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2944310-B1 | MIF inhibitors for the acute or chronic treatment of pulmonary hypertension | MIFCARE (FR) | 2018-03-21 | — | — | EP | disclosed |