Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 4/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | CES2 | O00748 | 3/20 | 0.33 |
| ▸ | THRB | P10828 | 2/20 | 0.33 |
| ▸ | GMNN | O75496 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | THRA | P10827 | 1/20 | 0.32 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.31 |
| ▸ | FAAH | O00519 | 4/20 | 0.30 |
| ▸ | CES1 | P23141 | 4/20 | 0.30 |
| ▸ | PLA2G6 | O60733 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19985154 | 0.86 | EPHX2 (0.32) | EPHX2 | |
| SCHEMBL13854238 | 0.82 | EPHX2 (0.46) | EPHX2TP53MAPTCYP2C9HSD17B10 | |
| SCHEMBL14497589 | 0.74 | EPHX2 (0.58) | EPHX2 | |
| SCHEMBL17424798 | 0.70 | GMNN (0.49) | ESR1ESR2CES2THRBGMNN | |
| SCHEMBL4204194 | 0.69 | EPHX2 (0.61) | EPHX2 | |
| SCHEMBL29191779 | 0.68 | PLA2G4B (0.41) | ESR1ESR2CES2THRBGMNN | |
| SCHEMBL29191780 | 0.66 | MGLL (0.48) | CES2THRBGMNNTP53POLB | |
| SCHEMBL19985162 | 0.65 | THRB (0.35) | ESR1ESR2CES2THRBGMNN | |
| SCHEMBL17231396 | 0.64 | ALDH1A1 (0.45) | EPHX2MAPT | |
| SCHEMBL4198695 | 0.64 | EPHX2 (0.57) | EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3142665-B1 | MIF INHIBITORS FOR THE ACUTE OR CHRONIC TREATMENT OF PULMONARY HYPERTENSION | APAXEN (BE) | 2021-01-20 | — | — | EP | disclosed |