Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 5/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | AXL | P30530 | 1/20 | 0.35 |
| ▸ | ATP4A | P20648 | 2/20 | 0.35 |
| ▸ | ATP4B | P51164 | 2/20 | 0.35 |
| ▸ | BRS3 | P32247 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.33 |
| ▸ | WDR5 | P61964 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.33 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6482632 | 0.84 | ATP4A (0.51) | AMY1AMAPTKMT2AALDH1A1CYP1A2 | |
| SCHEMBL9286820 | 0.84 | ATP4A (0.51) | AMY1AMAPTKMT2AALDH1A1CYP1A2 | |
| SCHEMBL12809663 | 0.82 | ATP4A (0.38) | AMY1AMAPTKMT2AALDH1A1CYP1A2 | |
| SCHEMBL15242103 | 0.82 | DYRK1A (0.35) | AMY1AMAPTKMT2AALDH1A1CYP1A2 | |
| SCHEMBL10699456 | 0.82 | GAA (0.36) | AMY1AMAPTKMT2AALDH1A1CYP1A2 | |
| SCHEMBL21671227 | 0.81 | BRS3 (0.45) | AMY1AMAPTKMT2AALDH1A1CYP1A2 | |
| Omeprazole SCHEMBL1560726 | 0.81 | BRS3 (0.52) | MAPTKMT2AALDH1A1CYP1A2CYP2C19 | |
| Omeprazole SCHEMBL1191 | 0.81 | BRS3 (0.52) | MAPTKMT2AALDH1A1CYP1A2CYP2C19 | |
| Esomeprazole SCHEMBL29673044 | 0.81 | BRS3 (0.52) | MAPTKMT2AALDH1A1CYP1A2CYP2C19 | |
| Omeprazole SCHEMBL82985 | 0.81 | BRS3 (0.52) | MAPTKMT2AALDH1A1CYP1A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116675674-A | Novel substituted benzimidazole derivatives as inhibitors of D-amino acid oxidase (DAAO) | 宇凤·简·曾 | 2023-09-01 | — | — | CN | claimed |
| CN-115504962-A | Benzimidazole derivatives for the treatment and/or prevention of diseases and disorders mediated by NLRP3 | 思捷优达股份有限公司 | 2022-12-23 | — | — | CN | claimed |
| US-20250250249-A1 | NOVEL SUBSTITUTED BENZIMIDAZOLE DERIVATIVES AS D-AMINO ACID OXIDASE (DAAO) INHIBITORS | NATIONAL YANG MING CHIAO TUNG UNIVERSITY (TW) | 2025-08-07 | — | — | US | disclosed |
| EP-4289425-A2 | NOVEL SUBSTITUTED BENZIMIDAZOLE DERIVATIVES AS D-AMINO ACID OXIDASE (DAAO) INHIBITORS | Tseng, Yufeng, Jane (US) | 2023-12-13 | — | — | EP | disclosed |
| CN-116675674-A | Novel substituted benzimidazole derivatives as inhibitors of D-amino acid oxidase (DAAO) | 宇凤·简·曾 | 2023-09-01 | — | — | CN | disclosed |
| CN-110234635-B | Novel substituted benzimidazole derivatives as D-amino oxidase (DAAO) inhibitors | 宇凤·简·曾 | 2023-03-10 | — | — | CN | disclosed |
| US-20230018423-A1 | BENZIMIDAZOLE DERIVATIVES FOR TREATMENT AND/OR PREVENTION OF DISEASES AND DISORDERS MEDIATED BY NLRP3 | YODA THERAPEUTICS INC. (TW) | 2023-01-19 | — | — | US | disclosed |
| US-20220267301-A1 | NOVEL SUBSTITUTED BENZIMIDAZOLE DERIVATIVES AS D-AMINO ACID OXIDASE (DAAO) INHIBITORS | NATIONAL CHIAO TUNG UNIVERSITY (TW) | 2022-08-25 | — | — | US | disclosed |
| US-11370775-B2 | Substituted benzimidazole derivatives as D-amino acid oxidase (DAAO) inhibitors | Tseng, Yufeng Jane (US) | 2022-06-28 | — | — | US | disclosed |
| US-20200361894-A1 | NOVEL SUBSTITUTED BENZIMIDAZOLE DERIVATIVES AS D-AMINO ACID OXIDASE (DAAO) INHIBITORS | NATIONAL YANG MING CHIAO TUNG UNIVERSITY (TW) | 2020-11-19 | — | — | US | disclosed |
| WO-2018053161-A1 | NOVEL SUBSTITUTED BENZIMIDAZOLE DERIVATIVES AS D-AMINO ACID OXIDASE (DAAO) INHIBITORS | NATIONAL TAIWAN UNIVERSITY (TW) | 2018-03-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250250249-A1 | NOVEL SUBSTITUTED BENZIMIDAZOLE DERIVATIVES AS D-AMINO ACID OXIDASE (DAAO) INHIBITORS | DAO, DDO, DDC | AMY1A 1490/4885MAPT 1040/4885KMT2A 943/4885 |
| US-20230018423-A1 | BENZIMIDAZOLE DERIVATIVES FOR TREATMENT AND/OR PREVENTION OF DISEASES AND DISORDERS MEDIATED BY NLRP3 | NLRP3, NOD1, NLRP1 | AMY1A 1523/4885MAPT 820/4885KMT2A 4102/4885 |
| US-11370775-B2 | Substituted benzimidazole derivatives as D-amino acid oxidase (DAAO) inhibitors | DAO, DDO, IL4I1 | AMY1A 1110/4885MAPT 1362/4885KMT2A 1384/4885 |
| US-20220267301-A1 | NOVEL SUBSTITUTED BENZIMIDAZOLE DERIVATIVES AS D-AMINO ACID OXIDASE (DAAO) INHIBITORS | DAO, DDO, DDC | AMY1A 1490/4885MAPT 1040/4885KMT2A 943/4885 |
| US-20200361894-A1 | NOVEL SUBSTITUTED BENZIMIDAZOLE DERIVATIVES AS D-AMINO ACID OXIDASE (DAAO) INHIBITORS | DAO, DDO, DDC | AMY1A 1490/4885MAPT 1040/4885KMT2A 943/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.