Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | TYMP | P19971 | 3/20 | 0.38 |
| ▸ | TK1 | P04183 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | ALB | P02768 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | TK2 | O00142 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20541413 | 0.80 | TYMP (0.40) | MAPK1TYMPTK1POLB | |
| SCHEMBL3025206 | 0.77 | MAPK1 (0.46) | MAPK1HPGDTYMPTK1ALDH1A1 | |
| SCHEMBL6703360 | 0.76 | MAPK1 (0.45) | MAPK1HPGDTYMPTK1ALDH1A1 | |
| SCHEMBL28505162 | 0.73 | MAPK1 (0.42) | MAPK1HPGDTYMPTK1ALDH1A1 | |
| SCHEMBL2635616 | 0.73 | MAPK1 (0.42) | MAPK1HPGDTYMPTK1ALDH1A1 | |
| SCHEMBL4342113 | 0.71 | TYMP (0.49) | MAPK1HPGDTYMPTK1 | |
| SCHEMBL8910349 | 0.71 | MAPK1 (0.41) | MAPK1HPGDTYMPTK1 | |
| SCHEMBL6911384 | 0.70 | TYMP (0.44) | MAPK1HPGDTYMPTK1 | |
| SCHEMBL7832846 | 0.69 | MAPK1 (0.43) | MAPK1HPGDTYMPTK1ALDH1A1 | |
| SCHEMBL21886851 | 0.69 | MAPK1 (0.40) | MAPK1HPGDTYMPTK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3515923-A1 | PRODRUGS OF FLUORINATED ACYCLIC NUCLEOSIDE PHOSPHONATES | Katholieke Universiteit Leuven (BE) | 2019-07-31 | — | — | EP | disclosed |
| WO-2018055071-A1 | PRODRUGS OF FLUORINATED ACYCLIC NUCLEOSIDE PHOSPHONATES | KATHOLIEKE UNIVERSITEIT LEUVEN (BE) | 2018-03-29 | — | — | WO | disclosed |