Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.41 |
| ▸ | TYMP | P19971 | 3/20 | 0.38 |
| ▸ | TK1 | P04183 | 5/20 | 0.37 |
| ▸ | TK2 | O00142 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11257611 | 0.74 | TK1 (0.49) | MAPK1HPGDTYMPTK1TK2 | |
| SCHEMBL3025206 | 0.72 | MAPK1 (0.46) | MAPK1HPGDADRA1ATYMPTK1 | |
| SCHEMBL6703360 | 0.70 | MAPK1 (0.45) | MAPK1HPGDTYMPTK1ALDH1A1 | |
| SCHEMBL2183944 | 0.70 | MAPK1 (0.61) | MAPK1HPGDTYMPTK1TK2 | |
| SCHEMBL19995056 | 0.69 | MAPK1 (0.44) | MAPK1HPGDADRA1ATYMPTK1 | |
| SCHEMBL6911384 | 0.69 | TYMP (0.44) | MAPK1HPGDTYMPTK1 | |
| Ammonia Solution, Strong SCHEMBL4194711 | 0.68 | MAPK1 (0.59) | MAPK1HPGDTYMPTK1TK2 | |
| SCHEMBL19639709 | 0.68 | MAPK1 (0.42) | MAPK1HPGDADRA1ATYMPTK1 | |
| SCHEMBL28505162 | 0.68 | MAPK1 (0.42) | MAPK1HPGDADRA1ATYMPTK1 | |
| SCHEMBL2635616 | 0.68 | MAPK1 (0.42) | MAPK1HPGDTYMPTK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0748800-B1 | Pyrimidinedione, pyrimidinetrione, triazinedione derivatives as alpha-1-adrenergic receptor antagonists | HOFFMANN LA ROCHE (CH) | 2001-05-09 | — | — | EP | disclosed |
| US-5859014-A | USEFUL IN TREATMENT OF DISEASES INVOLVING DIRECTLY OR INDIRECTLY AN OBSTRUCTION OF THE LOWER URINARY TRACT, SUCH ASBENIGN PROSTATE HYPERPLASIA | SYNTEX (U.S.A.) INC. (US) | 1999-01-12 | — | — | US | disclosed |
| EP-0748800-A2 | Pyrimidinedione, pyrimidinetrione, triazinedione, tetrahydroquinazolinedione derivatives as alpha-1-adrenergic receptor antagonists | F. HOFFMANN-LA ROCHE AG (CH) | 1996-12-18 | — | — | EP | disclosed |