Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA5 | P31644 | 1/20 | 0.47 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.45 |
| ▸ | NOS1 | P29475 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17709802 | 0.92 | LMNA (0.47) | GABRA5GABRB2HSD17B10LMNASMN1; SMN2 | |
| SCHEMBL15549396 | 0.91 | LMNA (0.46) | GABRA5GABRB2HSD17B10LMNASMN1; SMN2 | |
| SCHEMBL6415421 | 0.74 | ALDH1A1 (0.43) | HSD17B10LMNASMN1; SMN2NOS1MAPT | |
| SCHEMBL1970795 | 0.74 | NOS1 (0.44) | GABRA5GABRB2HSD17B10LMNASMN1; SMN2 | |
| SCHEMBL2567076 | 0.72 | — | — | |
| SCHEMBL5875718 | 0.71 | GABRA5 (0.54) | GABRA5GABRB2HSD17B10SMN1; SMN2MAPT | |
| SCHEMBL17709923 | 0.71 | HTR6 (0.34) | NPC1 | |
| SCHEMBL18391843 | 0.70 | — | — | |
| SCHEMBL77889 | 0.70 | — | — | |
| SCHEMBL3509445 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018058109-A1 | COMPOSITIONS AND METHODS FOR TREATING METABOLIC DISORDERS | NUSIRT SCIENCES, INC. (US) | 2018-03-29 | — | — | WO | disclosed |