Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 2/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.33 |
| ▸ | CA2 | P00918 | 2/20 | 0.33 |
| ▸ | CA4 | P22748 | 2/20 | 0.33 |
| ▸ | CA9 | Q16790 | 2/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | TRPC6 | Q9Y210 | 4/20 | 0.33 |
| ▸ | TACR1 | P25103 | 1/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20002280 | 0.85 | TACR1 (0.40) | RORCTACR1HSD11B1 | |
| SCHEMBL20002167 | 0.80 | KDM1A (0.40) | RORCSMN1; SMN2 | |
| SCHEMBL20002664 | 0.77 | TSHR (0.41) | HSD11B1SMN1; SMN2 | |
| SCHEMBL20002990 | 0.77 | RORC (0.40) | RORCCA1CA2CA4CA9 | |
| SCHEMBL20002669 | 0.76 | NOTUM (0.45) | RORCHSD11B1SMN1; SMN2 | |
| SCHEMBL20002958 | 0.76 | NOTUM (0.48) | RORCHSD11B1SMN1; SMN2 | |
| SCHEMBL20002957 | 0.76 | NOTUM (0.48) | RORCHSD11B1SMN1; SMN2 | |
| SCHEMBL20002969 | 0.76 | NOTUM (0.45) | RORCHSD11B1SMN1; SMN2 | |
| SCHEMBL20003049 | 0.76 | AKR1C3 (0.51) | HSD11B1SMN1; SMN2 | |
| SCHEMBL20003029 | 0.75 | RORC (0.41) | RORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3092229-B1 | PYRROLIDINYL SULFONE DERIVATIVES AND THEIR USE AS ROR GAMMA MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2018-03-28 | — | — | EP | disclosed |