Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 7/20 | 0.39 |
| ▸ | RORC | P51449 | 6/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20002958 | 1.00 | NOTUM (0.48) | NOTUMMAPTHSD11B1RORCLMNA | |
| SCHEMBL20002669 | 0.95 | NOTUM (0.45) | NOTUMMAPTHSD11B1RORCLMNA | |
| SCHEMBL20002969 | 0.95 | NOTUM (0.45) | NOTUMMAPTHSD11B1RORCLMNA | |
| SCHEMBL20002341 | 0.94 | MAPT (0.48) | NOTUMMAPTRORCKMT2AALDH1A1 | |
| SCHEMBL20002250 | 0.94 | MAPT (0.48) | NOTUMMAPTRORCKMT2AALDH1A1 | |
| SCHEMBL20002751 | 0.85 | NOTUM (0.42) | NOTUMMAPTRORC | |
| SCHEMBL20002773 | 0.85 | RORC (0.44) | NOTUMMAPTHSD11B1RORCLMNA | |
| SCHEMBL20003049 | 0.83 | AKR1C3 (0.51) | HSD11B1LMNAKMT2AAKR1C3ALDH1A1 | |
| SCHEMBL20002280 | 0.83 | TACR1 (0.40) | HSD11B1RORCAKR1C3 | |
| SCHEMBL20002167 | 0.83 | KDM1A (0.40) | RORCLMNAAKR1C3ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3092229-B1 | PYRROLIDINYL SULFONE DERIVATIVES AND THEIR USE AS ROR GAMMA MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2018-03-28 | — | — | EP | disclosed |