Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 2/20 | 0.35 |
| ▸ | TACR3 | P29371 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | GFER | P55789 | 1/20 | 0.30 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20002752 | 0.81 | TACR3 (0.34) | RORCTACR3 | |
| SCHEMBL20002965 | 0.80 | RORC (0.34) | RORCTACR3SMN1; SMN2GFER | |
| SCHEMBL20002796 | 0.78 | RORC (0.45) | RORCSMN1; SMN2PDK2 | |
| SCHEMBL20003052 | 0.77 | HSD11B1 (0.38) | RORCTACR3SMN1; SMN2GFER | |
| SCHEMBL20002166 | 0.73 | RORC (0.40) | RORCTACR3SMN1; SMN2 | |
| SCHEMBL20002187 | 0.73 | RORC (0.44) | RORCSMN1; SMN2 | |
| SCHEMBL20002819 | 0.73 | RORC (0.44) | RORCSMN1; SMN2 | |
| SCHEMBL20002856 | 0.72 | RORC (0.42) | RORCSMN1; SMN2 | |
| SCHEMBL20003241 | 0.71 | RORC (0.41) | RORCSMN1; SMN2 | |
| SCHEMBL20002171 | 0.71 | KMT2A (0.38) | RORCSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3092229-B1 | PYRROLIDINYL SULFONE DERIVATIVES AND THEIR USE AS ROR GAMMA MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2018-03-28 | — | — | EP | disclosed |