Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 3/20 | 0.44 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 6/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20002969 | 0.85 | NOTUM (0.45) | RORCNOTUMMAPTHSD11B1RAB9A | |
| SCHEMBL20002669 | 0.85 | NOTUM (0.45) | RORCNOTUMMAPTHSD11B1RAB9A | |
| SCHEMBL20002957 | 0.85 | NOTUM (0.48) | RORCNOTUMMAPTHSD11B1KMT2A | |
| SCHEMBL20002958 | 0.85 | NOTUM (0.48) | RORCNOTUMMAPTHSD11B1KMT2A | |
| SCHEMBL20002341 | 0.82 | MAPT (0.48) | RORCNOTUMMAPTRAB9AKMT2A | |
| SCHEMBL20002250 | 0.82 | MAPT (0.48) | RORCNOTUMMAPTRAB9AKMT2A | |
| SCHEMBL20002751 | 0.81 | NOTUM (0.42) | RORCNOTUMMAPTL3MBTL1 | |
| SCHEMBL20002559 | 0.76 | ALDH1A1 (0.45) | RORCNOTUMMAPTNPC1KMT2A | |
| SCHEMBL20002207 | 0.76 | RORC (0.45) | RORCNOTUMMAPTNPC1RAB9A | |
| SCHEMBL20002280 | 0.76 | TACR1 (0.40) | RORCHSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3092229-B1 | PYRROLIDINYL SULFONE DERIVATIVES AND THEIR USE AS ROR GAMMA MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2018-03-28 | — | — | EP | disclosed |