Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.42 |
| ▸ | SLC6A1 | P30531 | 2/20 | 0.40 |
| ▸ | RORC | P51449 | 5/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SLC6A11 | P48066 | 1/20 | 0.38 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20002250 | 1.00 | MAPT (0.48) | MAPTNOTUMSLC6A1RORCRAB9A | |
| SCHEMBL20002958 | 0.94 | NOTUM (0.48) | MAPTNOTUMRORCALDH1A1KMT2A | |
| SCHEMBL20002957 | 0.94 | NOTUM (0.48) | MAPTNOTUMRORCALDH1A1KMT2A | |
| SCHEMBL20002669 | 0.90 | NOTUM (0.45) | MAPTNOTUMRORCRAB9AALDH1A1 | |
| SCHEMBL20002969 | 0.90 | NOTUM (0.45) | MAPTNOTUMRORCRAB9AALDH1A1 | |
| SCHEMBL20002229 | 0.86 | MEN1 (0.38) | MAPTRORCRAB9AGRM3MEN1 | |
| SCHEMBL20002698 | 0.83 | HSD11B1 (0.47) | RORCMAPK1MEN1ALDH1A1KMT2A | |
| SCHEMBL20002706 | 0.83 | HSD11B1 (0.47) | RORCMAPK1MEN1ALDH1A1KMT2A | |
| SCHEMBL20002751 | 0.82 | NOTUM (0.42) | MAPTNOTUMRORC | |
| SCHEMBL20002773 | 0.82 | RORC (0.44) | MAPTNOTUMRORCRAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3092229-B1 | PYRROLIDINYL SULFONE DERIVATIVES AND THEIR USE AS ROR GAMMA MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2018-03-28 | — | — | EP | disclosed |