Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 2/20 | 0.53 |
| ▸ | HTR2A | P28223 | 5/20 | 0.40 |
| ▸ | HTR2C | P28335 | 4/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 2/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.37 |
| ▸ | GPR6 | P46095 | 1/20 | 0.36 |
| ▸ | MMP13 | P45452 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | GCK | P35557 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 2/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20002244 | 0.81 | RORC (0.46) | RORCHTR2AHTR2CKCNH2EPHX2 | |
| SCHEMBL20002210 | 0.78 | RORC (0.44) | RORCDRD2JAK1JAK2 | |
| SCHEMBL20002448 | 0.78 | EPHX2 (0.44) | RORCHTR2AHTR2CKCNH2EPHX2 | |
| SCHEMBL21426003 | 0.77 | MMP13 (0.53) | RORCNAMPTMMP13 | |
| SCHEMBL21426007 | 0.77 | MMP13 (0.53) | RORCNAMPTMMP13 | |
| SCHEMBL14413535 | 0.73 | EPHX2 (0.47) | RORCHTR2AHTR2CKCNH2EPHX2 | |
| SCHEMBL20003003 | 0.73 | EPHX2 (0.45) | RORCHTR2AHTR2CKCNH2EPHX2 | |
| SCHEMBL13890294 | 0.73 | EPHX2 (0.50) | HTR2AHTR2CKCNH2EPHX2DRD2 | |
| SCHEMBL20002502 | 0.72 | L3MBTL1 (0.64) | NAMPTMMP13L3MBTL1 | |
| SCHEMBL4777810 | 0.72 | MMP13 (0.58) | RORCNAMPTMMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3092229-B1 | PYRROLIDINYL SULFONE DERIVATIVES AND THEIR USE AS ROR GAMMA MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2018-03-28 | — | — | EP | disclosed |