Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 1/20 | 0.44 |
| ▸ | JAK1 | P23458 | 3/20 | 0.35 |
| ▸ | JAK2 | O60674 | 2/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.34 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | DRD4 | P21917 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20002956 | 0.84 | RORC (0.44) | RORCGPR119PDK2POLBLMNA | |
| SCHEMBL20002870 | 0.80 | PDK2 (0.38) | RORCPDK2KMT2ALMNAHSD11B1 | |
| SCHEMBL20002931 | 0.78 | PDK2 (0.39) | RORCPDK2POLBDRD2DRD4 | |
| SCHEMBL20002953 | 0.78 | RORC (0.53) | RORCJAK1JAK2DRD2 | |
| SCHEMBL20002917 | 0.77 | MEN1 (0.47) | JAK1JAK2GPR119POLBKMT2A | |
| SCHEMBL20002981 | 0.74 | KDM4E (0.55) | POLBKMT2ALMNAHSD11B1NPC1 | |
| SCHEMBL4773698 | 0.72 | MEN1 (0.51) | GPR119POLBKMT2ANPC1RAB9A | |
| SCHEMBL20002280 | 0.71 | TACR1 (0.40) | RORCHSD11B1 | |
| SCHEMBL20002167 | 0.71 | KDM1A (0.40) | RORCLMNANPC1RAB9A | |
| SCHEMBL20003029 | 0.71 | RORC (0.41) | RORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3092229-B1 | PYRROLIDINYL SULFONE DERIVATIVES AND THEIR USE AS ROR GAMMA MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2018-03-28 | — | — | EP | disclosed |