Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.64 |
| ▸ | SLC18A3 | Q16572 | 2/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.47 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.47 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.47 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.47 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.47 |
| ▸ | NAMPT | P43490 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MMP1 | P03956 | 1/20 | 0.46 |
| ▸ | MMP3 | P08254 | 1/20 | 0.46 |
| ▸ | MMP7 | P09237 | 1/20 | 0.46 |
| ▸ | MMP9 | P14780 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20003002 | 0.83 | TSHR (0.48) | L3MBTL1RAB9AALDH1A1MAPK1NAMPT | |
| SCHEMBL20003085 | 0.81 | PROKR1 (0.44) | L3MBTL1RAB9APOLBNAMPTGAA | |
| SCHEMBL20003091 | 0.80 | RORC (0.54) | L3MBTL1RAB9AALDH1A1LMNANAMPT | |
| SCHEMBL20002270 | 0.77 | KMT2A (0.60) | RAB9AALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL14413535 | 0.76 | EPHX2 (0.47) | L3MBTL1POLBCYP3A4 | |
| SCHEMBL20003016 | 0.76 | RORC (0.50) | L3MBTL1RAB9AALDH1A1LMNAPOLB | |
| SCHEMBL6209453 | 0.76 | SLC18A3 (0.75) | SLC18A3POLBGAA | |
| SCHEMBL20003147 | 0.76 | RORC (0.51) | RAB9AALDH1A1 | |
| SCHEMBL20002837 | 0.75 | RORC (0.49) | ALDH1A1NAMPTSMN1; SMN2 | |
| SCHEMBL15017250 | 0.75 | VNN1 (0.65) | SLC18A3ALDH1A1MAPK1POLBCHRNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3092229-B1 | PYRROLIDINYL SULFONE DERIVATIVES AND THEIR USE AS ROR GAMMA MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2018-03-28 | — | — | EP | disclosed |