Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.44 |
| ▸ | NAMPT | P43490 | 5/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 4/20 | 0.41 |
| ▸ | AKT1 | P31749 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20002502 | 0.81 | L3MBTL1 (0.64) | NAMPTL3MBTL1RAB9APOLBGAA | |
| SCHEMBL20002270 | 0.76 | KMT2A (0.60) | HTR2AHTR2CKCNH2HSD11B1CA12 | |
| SCHEMBL14413535 | 0.76 | EPHX2 (0.47) | EPHX2HTR2AHTR2CKCNH2L3MBTL1 | |
| SCHEMBL20003016 | 0.76 | RORC (0.50) | NAMPTEPHX2HTR2AHTR2CKCNH2 | |
| SCHEMBL20003147 | 0.75 | RORC (0.51) | EPHX2HTR2AHTR2CKCNH2HSD11B1 | |
| SCHEMBL20003003 | 0.72 | EPHX2 (0.45) | EPHX2HTR2AHTR2CKCNH2L3MBTL1 | |
| SCHEMBL20002563 | 0.72 | EPHX2 (0.45) | EPHX2HTR2AHTR2CKCNH2L3MBTL1 | |
| SCHEMBL13890294 | 0.72 | EPHX2 (0.50) | EPHX2HTR2AHTR2CKCNH2L3MBTL1 | |
| SCHEMBL20002837 | 0.72 | RORC (0.49) | NAMPTEPHX2HTR2AHTR2CKCNH2 | |
| SCHEMBL20003031 | 0.72 | EPHX2 (0.44) | NAMPTEPHX2HTR2AHTR2CKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3092229-B1 | PYRROLIDINYL SULFONE DERIVATIVES AND THEIR USE AS ROR GAMMA MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2018-03-28 | — | — | EP | disclosed |