Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 9/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | NAMPT | P43490 | 2/20 | 0.44 |
| ▸ | AKT1 | P31749 | 1/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | TACR3 | P29371 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | FNTA | P49354 | 1/20 | 0.42 |
| ▸ | FNTB | P49356 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20003002 | 0.87 | TSHR (0.48) | RORCALDH1A1SMN1; SMN2NAMPTKDM4E | |
| SCHEMBL20002690 | 0.84 | PRKAA2 (0.50) | RORCALDH1A1SMN1; SMN2AKT1PIK3CA | |
| SCHEMBL20002808 | 0.77 | RORC (0.53) | RORCALDH1A1SMN1; SMN2NAMPTEPHX2 | |
| SCHEMBL14413535 | 0.76 | EPHX2 (0.47) | RORCEPHX2HTR2AHTR2CKCNH2 | |
| SCHEMBL20002218 | 0.76 | SMN1; SMN2 (0.47) | RORCALDH1A1SMN1; SMN2CYP19A1KDM4E | |
| SCHEMBL20002209 | 0.76 | SMN1; SMN2 (0.47) | RORCALDH1A1SMN1; SMN2CYP19A1KDM4E | |
| SCHEMBL20003130 | 0.76 | ALDH1A1 (0.49) | RORCALDH1A1SMN1; SMN2CYP19A1KDM4E | |
| SCHEMBL20002502 | 0.75 | L3MBTL1 (0.64) | ALDH1A1SMN1; SMN2NAMPT | |
| SCHEMBL19702674 | 0.75 | SMN1; SMN2 (0.54) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL20002488 | 0.74 | RORC (0.47) | RORCALDH1A1KDM4EEPHX2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3092229-B1 | PYRROLIDINYL SULFONE DERIVATIVES AND THEIR USE AS ROR GAMMA MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2018-03-28 | — | — | EP | disclosed |