Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR3 | P29371 | 2/20 | 0.33 |
| ▸ | RORC | P51449 | 4/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.31 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | DRD4 | P21917 | 1/20 | 0.31 |
| ▸ | MGLL | Q99685 | 1/20 | 0.30 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20002976 | 0.80 | RORC (0.43) | RORCHCRTR1HCRTR2DRD4 | |
| SCHEMBL20002561 | 0.80 | RORC (0.50) | RORCGRIN2B | |
| SCHEMBL20003110 | 0.79 | RORC (0.41) | RORCGRIN2BHCRTR1HCRTR2DRD4 | |
| SCHEMBL20002735 | 0.76 | RORC (0.47) | RORC | |
| SCHEMBL20003077 | 0.75 | RORC (0.48) | RORCHCRTR1HCRTR2DRD4 | |
| SCHEMBL20002767 | 0.72 | RORC (0.43) | RORCSMN1; SMN2LMNA | |
| SCHEMBL20003010 | 0.72 | RORC (0.43) | RORCALDH1A1 | |
| SCHEMBL20002748 | 0.67 | RORC (0.39) | RORCALDH1A1SMN1; SMN2KMT2ALMNA | |
| SCHEMBL20002622 | 0.66 | RORC (0.49) | RORCALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL20003044 | 0.66 | RORC (0.40) | RORCALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3092229-B1 | PYRROLIDINYL SULFONE DERIVATIVES AND THEIR USE AS ROR GAMMA MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2018-03-28 | — | — | EP | disclosed |