Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 6/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 5/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.31 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.31 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.31 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.31 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.31 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.31 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.31 |
| ▸ | DRD4 | P21917 | 2/20 | 0.30 |
| ▸ | HTR2C | P28335 | 1/20 | 0.30 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20002561 | 0.88 | RORC (0.50) | RORCGRIN2B | |
| SCHEMBL20002622 | 0.88 | RORC (0.49) | RORCCYP3A4 | |
| SCHEMBL20003094 | 0.79 | TACR3 (0.33) | RORCGRIN2BHCRTR2HCRTR1DRD4 | |
| SCHEMBL20002976 | 0.79 | RORC (0.43) | RORCHCRTR2HCRTR1DRD4 | |
| SCHEMBL20002748 | 0.77 | RORC (0.39) | RORC | |
| SCHEMBL20002735 | 0.77 | RORC (0.47) | RORC | |
| SCHEMBL20003077 | 0.74 | RORC (0.48) | RORCHCRTR2HCRTR1DRD4 | |
| SCHEMBL20003111 | 0.73 | RORC (0.36) | RORC | |
| SCHEMBL20003010 | 0.73 | RORC (0.43) | RORC | |
| SCHEMBL20002767 | 0.71 | RORC (0.43) | RORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3092229-B1 | PYRROLIDINYL SULFONE DERIVATIVES AND THEIR USE AS ROR GAMMA MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2018-03-28 | — | — | EP | disclosed |