Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 0.60 |
| ▸ | TRPV4 | Q9HBA0 | 19/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20003532 | 0.84 | ACLY (0.53) | TRPV4CYP3A4 | |
| SCHEMBL12424482 | 0.81 | TSHR (0.56) | CYP19A1TRPV4CYP3A4KCNH2 | |
| SCHEMBL20007287 | 0.81 | TRPV4 (0.55) | TRPV4 | |
| SCHEMBL21511374 | 0.81 | CYP19A1 (0.53) | CYP19A1TRPV4CYP3A4KCNH2 | |
| SCHEMBL21512380 | 0.81 | CYP19A1 (0.53) | CYP19A1TRPV4CYP3A4KCNH2 | |
| SCHEMBL5103723 | 0.79 | CYP19A1 (0.56) | CYP19A1TRPV4CYP3A4KCNH2 | |
| SCHEMBL20003613 | 0.79 | TRPV4 (0.55) | TRPV4CYP3A4 | |
| SCHEMBL12384634 | 0.78 | TRPV4 (0.49) | CYP19A1TRPV4CYP3A4KCNH2 | |
| SCHEMBL21512916 | 0.76 | CYP19A1 (0.60) | CYP19A1TRPV4CYP3A4KCNH2 | |
| SCHEMBL21512791 | 0.76 | CYP19A1 (0.60) | CYP19A1TRPV4CYP3A4KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018055526-A1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2018-03-29 | — | — | WO | disclosed |