Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 15/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.47 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30266475 | 0.87 | TRPV4 (0.48) | TRPV4MEN1ALDH1A1TSHRKMT2A | |
| SCHEMBL20003532 | 0.84 | ACLY (0.53) | TRPV4TSHRKMT2ACYP3A4CYP2C19 | |
| SCHEMBL20003506 | 0.79 | CYP19A1 (0.60) | TRPV4CYP3A4 | |
| SCHEMBL5244455 | 0.78 | TSHR (0.53) | TRPV4MEN1ALDH1A1TSHRKMT2A | |
| SCHEMBL8049836 | 0.76 | EPHX2 (0.45) | TRPV4HCRTR1HCRTR2EPHX2 | |
| SCHEMBL5716992 | 0.75 | RAB9A (0.61) | MEN1ALDH1A1TSHRKMT2ACYP2C19 | |
| SCHEMBL5717158 | 0.75 | RAB9A (0.61) | MEN1ALDH1A1TSHRKMT2ACYP2C19 | |
| SCHEMBL20003550 | 0.74 | TRPV4 (0.58) | TRPV4MEN1ALDH1A1TSHRKMT2A | |
| SCHEMBL20007988 | 0.74 | TRPV4 (0.58) | TRPV4MEN1ALDH1A1TSHRKMT2A | |
| SCHEMBL5717058 | 0.74 | HCRTR1 (0.50) | TRPV4MEN1ALDH1A1TSHRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018055526-A1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2018-03-29 | — | — | WO | disclosed |