Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACLY | P53396 | 1/20 | 0.53 |
| ▸ | TRPV4 | Q9HBA0 | 10/20 | 0.52 |
| ▸ | TSHR | P16473 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.46 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20003506 | 0.84 | CYP19A1 (0.60) | TRPV4CYP3A4 | |
| SCHEMBL20003613 | 0.84 | TRPV4 (0.55) | TRPV4TSHRKMT2ACYP3A4CYP2C19 | |
| SCHEMBL20007287 | 0.84 | TRPV4 (0.55) | ACLYTRPV4 | |
| SCHEMBL14034045 | 0.82 | CNR1 (0.55) | ACLYHTTCYP3A4CYP2C19 | |
| SCHEMBL21511418 | 0.78 | CNR2 (0.45) | ACLYTRPV4TSHRLMNAHPGD | |
| SCHEMBL21511851 | 0.78 | CNR2 (0.45) | ACLYTRPV4TSHRLMNAHPGD | |
| SCHEMBL3925070 | 0.78 | KMT2A (0.57) | TRPV4TSHRLMNAHPGDHTT | |
| SCHEMBL31212421 | 0.77 | TRPV4 (0.68) | ACLYTRPV4TSHRLMNAHTT | |
| SCHEMBL5093760 | 0.77 | TRPV4 (0.52) | ACLYTRPV4TSHRLMNAHPGD | |
| SCHEMBL4537385 | 0.77 | KMT2A (0.43) | ACLYTRPV4KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018055526-A1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2018-03-29 | — | — | WO | disclosed |