Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 6/20 | 0.43 |
| ▸ | ACLY | P53396 | 1/20 | 0.42 |
| ▸ | USP5 | P45974 | 1/20 | 0.42 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.41 |
| ▸ | TRPV4 | Q9HBA0 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | SLC13A5 | Q86YT5 | 1/20 | 0.41 |
| ▸ | F10 | P00742 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4537314 | 0.96 | POLB (0.44) | KMT2AMEN1EPHX2USP30TRPV4 | |
| SCHEMBL4537039 | 0.95 | EPHX2 (0.47) | KMT2AMEN1EPHX2USP5TRPV4 | |
| SCHEMBL4539756 | 0.88 | HDAC3 (0.50) | KMT2AEPHX2ACLYALDH1A1 | |
| SCHEMBL4535939 | 0.86 | USP30 (0.48) | KMT2AMEN1EPHX2ACLYUSP30 | |
| SCHEMBL4535273 | 0.85 | HTT (0.51) | KMT2AMEN1USP5POLBSLC13A5 | |
| SCHEMBL4538131 | 0.84 | HDAC3 (0.46) | KMT2AEPHX2POLBALDH1A1 | |
| SCHEMBL4535854 | 0.84 | KMT2A (0.47) | KMT2AMEN1SLC13A5ALDH1A1 | |
| SCHEMBL4535088 | 0.83 | USP30 (0.47) | KMT2AMEN1EPHX2USP30TRPV4 | |
| SCHEMBL4542825 | 0.82 | HDAC3 (0.53) | KMT2AEPHX2USP5ALDH1A1 | |
| SCHEMBL4530295 | 0.82 | POLB (0.44) | POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | claimed |
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |