Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 3/20 | 0.56 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.56 |
| ▸ | TEK | Q02763 | 2/20 | 0.56 |
| ▸ | MET | P08581 | 11/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | RET | P07949 | 1/20 | 0.43 |
| ▸ | KIT | P10721 | 1/20 | 0.43 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30074424 | 0.90 | KDR (0.57) | KDREPHB4TEKMETNPC1 | |
| SCHEMBL453535 | 0.87 | RAB9A (0.53) | KDREPHB4TEKMETNPC1 | |
| SCHEMBL20003607 | 0.83 | MET (0.56) | KDRTEKMETRAB9ARET | |
| SCHEMBL18256911 | 0.83 | KDR (0.52) | KDREPHB4TEKMETNPC1 | |
| SCHEMBL407809 | 0.82 | ALDH1A1 (0.56) | KDRMETSMN1; SMN2RETKIT | |
| Hydrochloric Acid SCHEMBL29453838 | 0.81 | ALDH1A1 (0.55) | KDRMETSMN1; SMN2RETKIT | |
| Water SCHEMBL2458178 | 0.81 | ALDH1A1 (0.55) | KDRMETSMN1; SMN2RETKIT | |
| SCHEMBL27778083 | 0.80 | KDR (0.43) | KDREPHB4TEKMETNPC1 | |
| SCHEMBL28520615 | 0.80 | MEN1 (0.53) | METNPC1RAB9A | |
| SCHEMBL22210779 | 0.80 | KDR (0.49) | KDREPHB4TEKMETNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105153028-B | Compound as c-Met kinase inhibitor | 南京爱德程医药科技有限公司 | 2019-03-26 | — | — | CN | claimed |
| CN-112142619-B | 1, 1-cyclopropane dicarboxylic acid amide compound and preparation method and application thereof | 浙江工业大学 | 2023-01-10 | — | — | CN | disclosed |
| CN-112142619-A | 1, 1-cyclopropane dicarboxylic acid amide compound and preparation method and application thereof | 浙江工业大学 | 2020-12-29 | — | — | CN | disclosed |
| EP-3299369-A1 | PYRIDO-AZAHETERECYDIC COMPOUND AND PREPARATION METHOD AND USE THEREOF | Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CN) | 2018-03-28 | — | — | EP | disclosed |