SCHEMBL20004842

SCHEMBL20004842

CCCCOc1cc(C)c(C#Cc2ccc(-c3cc(F)c4c(F)c(F)c(F)cc4c3)cc2)c(F)c1

nearest known ligand 0.36

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
RARB P10826 2/20 0.36
RARA P10276 1/20 0.36
MAOB P27338 1/20 0.34
CYP2D6 P10635 6/20 0.33
CYP3A4 P08684 4/20 0.33
MCHR1 Q99705 2/20 0.33
KDM4E B2RXH2 1/20 0.33
GAA P10253 1/20 0.33
HPGD P15428 1/20 0.33
CYSLTR2 Q9NS75 1/20 0.33
CYSLTR1 Q9Y271 1/20 0.33
CHRM1 P11229 1/20 0.33
HTR2A P28223 1/20 0.33
KAT6A Q92794 1/20 0.32
CYP2C9 P11712 8/20 0.32
CYP2C19 P33261 8/20 0.32
CYP19A1 P11511 7/20 0.32
CYP1A2 P05177 5/20 0.32
ACACB O00763 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19999400 0.82
SCHEMBL20004548 0.80 DRD2 (0.40) KDM4EGAAHPGDACACB
SCHEMBL20004632 0.79 RARA (0.33) RARBRARACYP2D6CYP3A4KDM4E
SCHEMBL20005218 0.79 RARA (0.36) RARBRARAMAOBCYP2D6CYP3A4
SCHEMBL19999608 0.78 HMOX1 (0.35) RARBRARACYSLTR2CYSLTR1ACACB
SCHEMBL20004622 0.78 MCHR1 (0.40) RARBRARAMAOBCYP2D6CYP3A4
SCHEMBL20004766 0.76 MAPT (0.39) RARBRARAMAOBMCHR1GAA
SCHEMBL19999600 0.76 RARB (0.35) RARBRARA
SCHEMBL19999409 0.75 ACACB (0.40) RARBRARACYP3A4ACACB
SCHEMBL19999353 0.75 ACACB (0.48) RARBRARAMCHR1CHRM1HTR2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3299439-A1 LIQUID CRYSTAL COMPOUND, LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE JNC Corporation (JP) 2018-03-28 EP disclosed