Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 2/20 | 0.74 |
| ▸ | TP53 | P04637 | 1/20 | 0.72 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.66 |
| ▸ | GHSR | Q92847 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.61 |
| ▸ | TSHR | P16473 | 2/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.61 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20006970 | 0.84 | TP53 (1.00) | PTGS2TP53MAPK1SMN1; SMN2GHSR | |
| SCHEMBL12585052 | 0.83 | MAPK1 (0.79) | PTGS2TP53MAPK1SMN1; SMN2GHSR | |
| SCHEMBL20006967 | 0.83 | TP53 (0.74) | TP53MAPK1SMN1; SMN2GHSRALDH1A1 | |
| SCHEMBL8375473 | 0.83 | PTGS2 (0.65) | PTGS2TP53SMN1; SMN2L3MBTL1MEN1 | |
| SCHEMBL9429364 | 0.83 | PTGS2 (0.62) | PTGS2TP53SMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL13501815 | 0.82 | ALDH1A1 (0.84) | PTGS2TP53MAPK1SMN1; SMN2GHSR | |
| SCHEMBL20006969 | 0.81 | MAPK1 (0.72) | PTGS2TP53MAPK1SMN1; SMN2GHSR | |
| SCHEMBL9428709 | 0.81 | PTGS2 (0.60) | PTGS2TP53SMN1; SMN2MEN1KMT2A | |
| SCHEMBL13733531 | 0.81 | PTGS2 (0.53) | PTGS2TP53MAPK1ALDH1A1L3MBTL1 | |
| SCHEMBL9429179 | 0.81 | PTGS2 (0.65) | PTGS2SMN1; SMN2ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018055235-A1 | ISOXAZOLE-AMIDES FOR TREATING CARDIAC DISEASES | UNIVERSITY OF HELSINKI (FI) | 2018-03-29 | — | — | WO | disclosed |