Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 1.00 |
| ▸ | TSHR | P16473 | 2/20 | 0.80 |
| ▸ | MEN1 | O00255 | 1/20 | 0.80 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.80 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.69 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.68 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.68 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.68 |
| ▸ | GHSR | Q92847 | 1/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.61 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.61 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.60 |
| ▸ | HTT | P42858 | 1/20 | 0.60 |
| ▸ | HPGD | P15428 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20006965 | 0.86 | TP53 (0.75) | TP53TSHRMEN1KMT2AMAPK1 | |
| SCHEMBL12585052 | 0.85 | MAPK1 (0.79) | TP53TSHRKMT2AMAPK1SMN1; SMN2 | |
| SCHEMBL20006967 | 0.85 | TP53 (0.74) | TP53TSHRMEN1KMT2AMAPK1 | |
| SCHEMBL20006968 | 0.84 | PTGS2 (0.74) | TP53TSHRMEN1KMT2AMAPK1 | |
| SCHEMBL20006962 | 0.84 | TP53 (0.72) | TP53TSHRMEN1KMT2AMAPK1 | |
| SCHEMBL13501815 | 0.84 | ALDH1A1 (0.84) | TP53TSHRMAPK1SMN1; SMN2GHSR | |
| SCHEMBL12319772 | 0.81 | CYP3A4 (1.00) | TP53TSHRMEN1KMT2AMAPK1 | |
| SCHEMBL20006969 | 0.81 | MAPK1 (0.72) | TP53TSHRMAPK1SMN1; SMN2GHSR | |
| SCHEMBL13501824 | 0.80 | KMT2A (0.69) | TP53TSHRMEN1KMT2AMAPK1 | |
| SCHEMBL13501814 | 0.79 | ALDH1A1 (0.68) | TP53TSHRMEN1KMT2AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018055235-A1 | ISOXAZOLE-AMIDES FOR TREATING CARDIAC DISEASES | UNIVERSITY OF HELSINKI (FI) | 2018-03-29 | — | — | WO | disclosed |