Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 6/20 | 0.41 |
| ▸ | RBP1 | P09455 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.32 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.32 |
| ▸ | FEN1 | P39748 | 1/20 | 0.32 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | CDK1 | P06493 | 1/20 | 0.32 |
| ▸ | NEK2 | P51955 | 1/20 | 0.32 |
| ▸ | PLK1 | P53350 | 1/20 | 0.32 |
| ▸ | NEK7 | Q8TDX7 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23613990 | 1.00 | TRPV4 (0.41) | TRPV4RBP1SMN1; SMN2ALDH1A1TSHR | |
| SCHEMBL20007310 | 0.83 | TRPV4 (0.49) | TRPV4 | |
| SCHEMBL20007811 | 0.83 | TRPV4 (0.41) | TRPV4RBP1SMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL20007244 | 0.83 | TRPV4 (0.46) | TRPV4POLBCXCR3 | |
| SCHEMBL20007241 | 0.79 | HTR2A (0.39) | TRPV4RBP1SMN1; SMN2ALDH1A1POLB | |
| SCHEMBL20007647 | 0.77 | RBP1 (0.39) | RBP1SMN1; SMN2ALDH1A1POLBMEN1 | |
| SCHEMBL20003572 | 0.75 | TRPV4 (0.50) | TRPV4RBP1MEN1KMT2A | |
| SCHEMBL23614038 | 0.73 | RBP1 (0.36) | RBP1SMN1; SMN2ALDH1A1POLBKMT2A | |
| SCHEMBL20007703 | 0.73 | TRPV4 (0.43) | TRPV4RBP1SMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL20007441 | 0.73 | POLB (0.56) | TRPV4SMN1; SMN2ALDH1A1POLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018055524-A1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2018-03-29 | — | — | WO | disclosed |