Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR4 | P31391 | 1/20 | 0.42 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.41 |
| ▸ | TMPRSS4 | Q9NRS4 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | G6PD | P11413 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.39 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.39 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31294730 | 0.82 | PTGDR2 (0.47) | SSTR4MRGPRX4ALDH1A1KDM4EMEN1 | |
| SCHEMBL313562 | 0.82 | KIF11 (0.45) | SSTR4MRGPRX4ALDH1A1KDM4EMEN1 | |
| SCHEMBL31294779 | 0.82 | PTGDR2 (0.45) | SSTR4MRGPRX4ALDH1A1KDM4EMEN1 | |
| SCHEMBL18528840 | 0.81 | TRPV4 (0.43) | SSTR4MRGPRX4ALDH1A1KDM4EMEN1 | |
| SCHEMBL7076049 | 0.81 | ALDH1A1 (0.56) | SSTR4MRGPRX4ALDH1A1KDM4EMEN1 | |
| SCHEMBL31294774 | 0.81 | MRGPRX4 (0.45) | MRGPRX4ALDH1A1KDM4EMEN1USP2 | |
| SCHEMBL9677946 | 0.79 | SLC6A9 (0.46) | SSTR4MRGPRX4ALDH1A1KDM4EMEN1 | |
| SCHEMBL5047649 | 0.78 | ALDH1A1 (0.41) | SSTR4MRGPRX4ALDH1A1KDM4EMEN1 | |
| SCHEMBL3644863 | 0.78 | APP (0.44) | MRGPRX4TMPRSS4TRPV4KCNH2APP | |
| SCHEMBL6734969 | 0.78 | TRPV4 (0.56) | ALDH1A1KDM4EMEN1MAPTALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3515887-B1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE IP NO 2 LTD (GB) | 2021-07-07 | — | — | EP | disclosed |
| WO-2018055524-A1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2018-03-29 | — | — | WO | disclosed |