Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | HPGD | P15428 | 5/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | CASP1 | P29466 | 1/20 | 0.47 |
| ▸ | CASP7 | P55210 | 1/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.46 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.46 |
| ▸ | TOP2A | P11388 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.45 |
| ▸ | TSHR | P16473 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 3/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6954239 | 0.86 | TRPV4 (0.53) | TRPV4ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL1402437 | 0.83 | TRPV4 (0.61) | TRPV4ALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL17106429 | 0.82 | TRPV4 (0.39) | TRPV4ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL6899032 | 0.82 | ALDH1A1 (0.56) | TRPV4ALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL5418640 | 0.81 | TRPV4 (0.59) | TRPV4ALDH1A1 | |
| SCHEMBL13126997 | 0.81 | IDO1 (0.45) | TRPV4ALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL459931 | 0.79 | MAOB (0.55) | ALDH1A1MEN1KMT2AHPGDMAPK1 | |
| SCHEMBL29804271 | 0.79 | MAOB (0.55) | ALDH1A1MEN1KMT2AHPGDMAPK1 | |
| SCHEMBL14468631 | 0.79 | TRPV4 (0.54) | TRPV4GAA | |
| SCHEMBL1964286 | 0.79 | TRPV4 (0.56) | TRPV4ALDH1A1MEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 90 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10774041-B2 | Process for the preparation of apremilast | Rao, Davuluri Ramamohan (IN) | 2020-09-15 | — | — | US | claimed |
| US-20190071401-A1 | Improved Process for the Preparation of Apremilast | DAVULURI RAMAMOHAN RAO (IN) | 2019-03-07 | — | — | US | claimed |
| US-20180037843-A1 | PERFUME SYSTEMS | PROCTER & GAMBLE (US) | 2018-02-08 | — | — | US | claimed |
| WO-2017179065-A1 | IMPROVED PROCESS FOR THE PREPARATION OF APREMILAST | DAVULURI RAMAMOHAN RAO (IN) | 2017-10-19 | — | — | WO | claimed |
| EP-2723841-B1 | PERFUME SYSTEMS | PROCTER & GAMBLE (US) | 2017-01-04 | — | — | EP | claimed |
| US-20160186093-A1 | PERFUME SYSTEMS | PROCTER & GAMBLE (US) | 2016-06-30 | — | — | US | claimed |
| US-9309487-B2 | Perfume systems | THE PROCTER & GAMBLE COMPANY (US) | 2016-04-12 | — | — | US | claimed |
| US-20140378360-A1 | PERFUME SYSTEMS | PROCTER & GAMBLE (US) | 2014-12-25 | — | — | US | claimed |
| EP-2723841-A1 | PERFUME SYSTEMS | The Procter and Gamble Company (US) | 2014-04-30 | — | — | EP | claimed |
| US-20120329696-A1 | PERFUME SYSTEMS | PROCTER & GAMBLE COMPANY, THE | 2012-12-27 | — | — | US | claimed |
| WO-2012177357-A1 | PERFUME SYSTEMS | THE PROCTER & GAMBLE COMPANY (US) | 2012-12-27 | — | — | WO | claimed |
| CN-113861517-B | Konjac glucomannan porous composite membrane, preparation method and application thereof | 云南中烟工业有限责任公司 | 2022-11-18 | — | — | CN | disclosed |
| CN-113861517-A | Konjac glucomannan porous composite membrane, preparation method and application thereof | 云南中烟工业有限责任公司 | 2021-12-31 | — | — | CN | disclosed |
| EP-3590940-B1 | HEXAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AND RELATED COMPOUNDS AS AUTOTAXIN (ATX) INHIBITORS AND AS INHIBITORS OF THE LYSOPHOSPHATIDIC ACID (LPA) PRODUCTION FOR TREATING E.G. RENAL DISEASES | HOFFMANN LA ROCHE (CH) | 2021-06-09 | — | — | EP | disclosed |
| EP-3502099-B1 | CYCLIC COMPOUND ACTING AS PDE4 INHIBITOR | MEDSHINE DISCOVERY INC (CN) | 2020-12-09 | — | — | EP | disclosed |
| WO-2012177357-A1 | PERFUME SYSTEMS | THE PROCTER & GAMBLE COMPANY (US) | 2012-12-27 | — | — | WO | disclosed |
| US-20120329696-A1 | PERFUME SYSTEMS | PROCTER & GAMBLE COMPANY, THE | 2012-12-27 | — | — | US | disclosed |
| WO-2012097116-A2 | ISOTOPOLOGUES OF ISOINDOLE DERIVATIVES | CELGENE CORPORATION (US) | 2012-07-19 | — | — | WO | disclosed |
| US-6790977-B2 | REACTING THE 3,4-DIALKOXY BENZONITRILE WITH AN ALKALI METAL HALIDE, FOLLOWED BY TREATING WITH HYDROCHLORIC ACID; HIGH YIELD AND A LOW COST STARTING MATERIAL | SINON CORPORATION (TW) | 2004-09-14 | — | — | US | disclosed |
| US-20040024239-A1 | Process for preparing 3,4-dihydroxy-benzonitrile | SINON CORPORATION (TW) | 2004-02-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10774041-B2 | Process for the preparation of apremilast | CMA1, APRT, QDPR | TRPV4 3126/4885ALDH1A1 27/4885MEN1 2857/4885 |
| US-20180037843-A1 | PERFUME SYSTEMS | TRPA1, PORCN, PLIN5 | TRPV4 134/4885ALDH1A1 1292/4885MEN1 3884/4885 |
| US-20040024239-A1 | Process for preparing 3,4-dihydroxy-benzonitrile | PAH, HCN4, HPD | TRPV4 297/4885ALDH1A1 303/4885MEN1 1383/4885 |
| US-20120329696-A1 | PERFUME SYSTEMS | TRPA1, PORCN, PLIN5 | TRPV4 134/4885ALDH1A1 1292/4885MEN1 3884/4885 |
| US-20190071401-A1 | Improved Process for the Preparation of Apremilast | QDPR, CMA1, ACE | TRPV4 3620/4885ALDH1A1 29/4885MEN1 2853/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.