Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 4/20 | 0.40 |
| ▸ | IDO1 | P14902 | 2/20 | 0.39 |
| ▸ | MPL | P40238 | 2/20 | 0.35 |
| ▸ | TMPRSS4 | Q9NRS4 | 1/20 | 0.34 |
| ▸ | KIF11 | P52732 | 1/20 | 0.33 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | DAO | P14920 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | CES2 | O00748 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29827588 | 0.69 | PDE2A (0.50) | PDE2AIDO1MPLPTPN5GAA | |
| SCHEMBL2147584 | 0.69 | PDE2A (0.50) | PDE2AIDO1MPLPTPN5GAA | |
| SCHEMBL20906637 | 0.69 | ALDH1A1 (0.40) | KIF11CES2TSHR | |
| SCHEMBL5756914 | 0.69 | PDE2A (0.46) | PDE2AIDO1MPLHSD11B1TSHR | |
| SCHEMBL30326145 | 0.69 | PDE2A (0.46) | PDE2AIDO1MPLHSD11B1TSHR | |
| SCHEMBL23912793 | 0.68 | VCAM1 (0.35) | KIF11 | |
| SCHEMBL24052102 | 0.68 | — | — | |
| SCHEMBL2459420 | 0.68 | PDE2A (0.48) | PDE2AIDO1MPLPTPN5GAA | |
| Lithium SCHEMBL2459422 | 0.68 | PDE2A (0.48) | PDE2AIDO1MPLPTPN5GAA | |
| SCHEMBL7601744 | 0.66 | CES2 (0.52) | PDE2AIDO1MPLKIF11CES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3515887-B1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE IP NO 2 LTD (GB) | 2021-07-07 | — | — | EP | disclosed |
| WO-2018055524-A1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2018-03-29 | — | — | WO | disclosed |