Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RBP1 | P09455 | 1/20 | 0.39 |
| ▸ | FPR2 | P25090 | 7/20 | 0.35 |
| ▸ | PROKR1 | Q8TCW9 | 7/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | HTT | P42858 | 3/20 | 0.34 |
| ▸ | GAA | P10253 | 4/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.31 |
| ▸ | NAMPT | P43490 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23613990 | 0.77 | TRPV4 (0.41) | RBP1SMN1; SMN2ALDH1A1KMT2AMEN1 | |
| SCHEMBL20007693 | 0.77 | TRPV4 (0.41) | RBP1SMN1; SMN2ALDH1A1KMT2AMEN1 | |
| SCHEMBL20007310 | 0.73 | TRPV4 (0.49) | — | |
| SCHEMBL20007244 | 0.73 | TRPV4 (0.46) | GAAPOLB | |
| SCHEMBL20007811 | 0.73 | TRPV4 (0.41) | RBP1SMN1; SMN2ALDH1A1KMT2AMEN1 | |
| SCHEMBL23613910 | 0.70 | HTR2A (0.46) | RBP1SMN1; SMN2ALDH1A1LMNAHTT | |
| SCHEMBL23613838 | 0.70 | TRPV4 (0.50) | RBP1SMN1; SMN2ALDH1A1LMNAHTT | |
| SCHEMBL20007271 | 0.69 | TRPV4 (0.43) | RBP1 | |
| SCHEMBL20003707 | 0.68 | TRPV4 (0.52) | RBP1ALDH1A1KMT2AMEN1 | |
| SCHEMBL23614038 | 0.68 | RBP1 (0.36) | RBP1FPR2PROKR1SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018055524-A1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2018-03-29 | — | — | WO | disclosed |